Grey's Anatomy star Jesse Williams and his wife of almost five years Aryn Drake-Lee are calling it quits.

They have not been photographed together since January of 2016 and there is no sign of Aryn on Jesse's Instagram page within the last two years.

The divorce was filed last week but it is unclear who chose to end the marriage, according to TMZ who broke the story.

They have two young children together, son Maceo, aged one, and daughter Sadie, who is three.

But Jesse isn't seeking sole custody, instead he wants to share joint custody of their children with his estranged wife.

The last event they were seen at together was at the Art Los Angeles Contemporary 2016 Opening Night at Barker Hangar on January 28, 2016 in Santa Monica, California.

Jesse and Aryn married in September of 2012, but were together long before his acting career took off.