Mamelodi Sundowns will host Orlando Pirates in Nedbank Cup quarter-final, while Baroka travel to Polokwane City.
The Brazilians and the Buccaneers will square off in the pick of the last-eight fixtures, with giant killers Baroka will visit Rise and Shine in a Limpopo derby.
Elswhere SuperSport United will host Mpumalanga Black Aces, while Free State Stars will welcome Bidvest Wits.
Fixtures will be played on the weekend of 24-26 April, with exact dates, venues and time still to be announced.
Full Draw:
SuperSport United vs Mpumalanga Black Aces
Polokwane City vs Baroka FC
Free State Stars vs Bidvest Wits
Mamelodi Sundowns vs Orlando Pirates