On-air personalityWhile studying at the University of Cape Town, Dlamini was a presenter for LIVE on 16 June 2010 after she made her debut screen appearance while covering the "Youth Day" and "World Cup celebrations" shows. She later co-hosted Mzansi Insider, a SABC 1's lifestyle show. In 2012, she resigned from the show in order to pursue a career in acting. In 2013, Minnie switched to sports broadcasting by co-hosting Soccerzonewith Thomas Mlambo until in 2016 when the show's format was changed by SABC 1. She has sinced co-hosted several local and international award ceremonies including the 14th Metro FM Music Awards, 2016 Africa Magic Viewers Choice Awards, the PSL Awards and the South African Film and Television Awards.
ActingIn 2010, Dlamini debuted as a film actress in Generations, a SABC 1 TV soap in which she made a guest appearance as Miranda. She went on to play a lead role as Zintle Lebone in the soap The Wild and as Nosipho Bogatsu in Rockville.
ModellingIn September 2011, Dlamini was announced as the new face of South African departmental store LEGit, with her own fashion range, the Minnie-Series.
PhilantropyIn 2014, Dlamini founded the Minnie Dlamini Foundation, a charity organization established with the aim of helping young South African girls have access to good education. On 15 July 2015, she announced via Twitter that her foundation will be sponsoring 29 students with their university fees